Among 3,315 women exposed to oral fluconazole from 7 through 22 weeks’ gestation, 147 experienced a miscarriage, compared with 563 among 13,246 unexposed matched women (women not exposed to antifungals). Researchers concluded there was a significantly increased risk of spontaneous abortion associated with fluconazole exposure.
“In this nationwide cohort in Denmark, oral fluconazole use in pregnancy was associated with a significantly increased risk of spontaneous abortion,” the authors write. “Until more data on the association are available, cautious prescribing of fluconazole in pregnancy may be advisable. Although the risk of stillbirth was not significantly increased, this outcome should be investigated further.”